Brad L. Burge
God desires that ALL people would accept God's love and salvation through Jesus Christ. God has compelled me to share information with the world relating to the biblical seven year tribulation in order to share Truth in a deceived world.
In the beginning was the Word, and the Word was with God, and the Word was God. He was with God in the beginning. Through Him all things were made; without Him nothing was made that has been made. In Him was life, and that life was the light of men. The light shines in the darkness, but the darkness has not understood it. (John 1:1-5)
Jesus answered, "I AM the way and the truth and the life. No one comes to the Father except through me." (John 14:6)
Thursday, April 24, 2008
Researchers said they had identified a chemical contaminating the blood-thinner heparin from China and also shown how it could cause a sometimes fatal allergic reaction in people.
The contaminant is oversulfated chondroitin sulfate, the researchers said, confirming earlier U.S. Food and Drug Administration findings.
It appears to activate two inflammatory pathways, causing severe allergic reactions and low blood pressure, Ram Sasisekharan of the Massachusetts Institute of Technology and colleagues reported in the New England Journal of Medicine.
"These results provide a potential link between the presence of chemical contaminant in heparin and the clinical symptoms observed in affected patients," Sasisekharan said in a statement.
Sasisekharan and another team also used a standard analytical method to find the contamination, which had been difficult to pinpoint before, and said it might be used to screen other batches.
The tainted heparin had been used by at least 81 U.S. patients who died soon afterwards. They had classic allergic reactions, with plummeting blood pressure, swelling of the larynx and other severe symptoms.
Their cases forced manufacturer Baxter International (BAX.N: Quote, Profile,Research) to recall the commonly used blood-thinner and caused a diplomatic squabble between U.S. and Chinese officials.
The chondroitin contaminant, derived from animal cartilage, has a structure very similar to that of heparin, taken from pig intestines. It thus cannot be identified with the tests normally used to inspect batches of heparin.
They tested oversulfated chondroitin sulfate taken from FDA samples and found it directly activated an extreme allergic reaction, called anaphylaxis, in pigs.
Oversulfated chondroitin sulfate is derived from a popular supplement used to treat arthritis, among other things. It can resemble heparin's active ingredient but is much cheaper, leading some experts to suspect it was added deliberately.
Chinese officials said on Monday they had tested batches of heparin used by patients who reported health problems and only some of these batches contained the contaminant. But the FDA countered this.